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Antibody Characterization

Interaction Analysis

The characterization of the interaction between a monoclonal antibody and its antigen is crucial for understanding the structural properties of an immuno-complex. Using chemical cross-linking and High-Mass MALDI mass spectrometry, it is possible to detemine with high-accuracy the mass of the antigen targeted by a monoclonal antibody. The stoechiometry of the interaction between the antigen and the antibody is also determined. This analysis is crucial when developing therapeutic antibodies.

Analysis of the complex formed by the bovine prion protein (bPrP) and a monoclonal antibody anti-bPrP (6H4). The complexes are analyzed before (Blue) and after cross-linking (red) with CovalX’s K200 MALDI MS analysis kit. After cross-linking, the non covalent complex 6H4-bPrP and 6H4-2bPrP are easily detected with m=172.5 and 196.1 kDa using CovalX’s High-Mass detection system HM1.

Bich et al. Anal. Biochem, 2008, 375:35-45.
Nazabal et al. Anal. Chem. 2006, 78(11), 3562-3570

For more details concerning Ab/Ag interaction analysis, feel free to contact our Customer Support Centers or email cro@covalx.com

They say when things are working, don’t try to fix them and we couldn’t agree more here at Candlewyck Cove Resort. As we sit nestled among the beauty nature offers us on this seven acres of northern Oklahoma, we know this is what doesn’t need fixing.

We have 450 feet of waterfront that gives our visitors some of the best beach space surrounding Grand Lake. We have trees galore with the creatures of nature to be admired and enjoyed by all that come here. We couldn’t think of anything to fix here if we had to.

But when it comes to the business side of Candlewyck Cove Resort, we know that things are changing and we need to keep up with it all. With that thought in mind, we’ve contracted with Quantus Creative LLC to design a new website for us.

Our new website will have more pictures of the beauty that our resort has to offer. It will also offer those with busy lives an easier way to make reservations, pay deposits and plan their family vacations or that special get-a-way for two, all online.

Not only will you be able to do all that by way of our new website, but you’ll be able to see more of what’s happening in the area around us, too. The places to eat and tour are plenty in this part of Oklahoma and Candlewyck Cove Resort is proud to show you all about it on our new website!

For those of you who know us and look forward to sharing your vacations with us, don’t worry. All the same things you’ve come to expect and love about Candlewyck Cove Resort is still here. After all, you can’t fix things that are working!

Those family vacations to theme parks are fun and it takes more than one visit to see it all. But once you have seen it all, well, you’ve seen it all. You and your kids are all bored with that same-old-same-old vacation and now you wonder just what you should do this summer instead.

How about getting back to nature? There are so many different private resorts and state parks that offer activities and relaxation, choosing which one to visit is the hardest part. They are nestled among trees and situated on beautiful lakes. You can bring a camper, tent or take advantage of cabins that may be available to rent. Just how much you want to “rough it” is up to you.

The best part of a vacation like this is getting you and your kids outside in the fresh air and sunshine. No pressure of getting to a show in time or standing in long lines for a 2 minute ride. You can sleep in or wake up early and enjoy the sunrise. Get to bed early or stay up late and watch the sun set and the stars sparkle.

After a vacation like these, you’ll return to work much more relaxed and rested than you do after spending 3 days traveling to a theme park for 2 days. The only thing that is going to change with nature is the seasons of time.

Make Your Summer Memories at a Lake Resort

Spring has arrived and families that don’t have their vacation plans in place already are starting to look at what there is to do and where to do it. All winter long, it’s been cold and everyone has been stuck inside. We’ve watched every Netflix series possible, played video games and surfed the internet until our eyes are crossed.

Now is the time to get that summer vacation planned and the places in Oklahoma are countless. We have some of the most beautiful lake resorts in the country. For the real outdoor type, there are camping grounds that are right on the lake or up in the woods. If roughing it isn’t your family’s style, then choose one of the many beautiful luxury hotels you could ask for.

Get other branches of the family together and rent out a cabin that is part of a lake resort and enjoy the many activities that are waiting. You don’t have to own a boat or a jet ski because there are lake rentals available for those things. You can have all the fun without the expense and worry of ownership.

This summer, take the kids out to enjoy the original form of social media. The many different resorts that the state of Oklahoma offers you are many and each one has its own beauty and fun. Choose a resort up in the mountains with a small lake or choose a resort on a larger lake with more activities. Either way, it can be a summer of fun and memories.

Lake Resort Camping Makes Camping Safer Today

Maybe this is the year to introduce the kids to outdoor fun they haven’t had before and take them to one of the many resorts in Oklahoma. In times gone by, it was common for a family to go camping during the summer. They would find a place close to the beach or a lake and pitch a tent, set up camp and have fun. Today though, it isn’t the same and camping has kind of fell off the radar of “things to do” for most of us.

Many will say that the kids aren’t interested. They have their computers and video games they’d rather play with. Or, they have organized sports that take up all the weekends. Then there are some who worry if camping out is even safe anymore. And that is a valid concern to have, especially when camping with the family.

Fortunately, there are many lake resorts around that offer cabins and camping grounds as well as luxury hotels and lake property rentals. A weekend away or the annual vacation, a resort is a more secured place to camp, making it safe for the entire family. Many life-long friendships have begun at resorts for adults and kids. Even when the camping is done and everyone heads back home, they can exchange contact information, even Facebook pages, and keep up with each other throughout the year.

Are Vacations in a Resort Better Than Going on Your Own?

Grand Lake Resorts – A misconception about vacationing at resorts is that they are exclusive and expensive. While there are many that are one or the other, and there or some that are both, not all are like that. Oklahoma has some of the most beautiful lake resorts and they are reasonably priced and open to the public. They may require a reservation, but you’ll soon find that you want that for your own convenience and sake.

Choose a lake resort that offers cabins of every size to luxury hotels that overlook a beautiful lake. There are resorts that offer cabins and hotels as well as camping grounds for those who want to “rough it’ for a weekend. The lodging is really up to you and just how comfortable you want to be or how adventurous you are. If small children are with you, the camping grounds are perfect for letting all that energy out.

Or, if you are looking for a romantic get-a-way, there is nothing more special than a hotel room at one of the state’s lake resorts. Many offer all the amenities that you would find at big city hotels like mints on the pillows and room service. Ask for a room with a lake view that sees the sun rise or the moon sit and you won’t be short of a romantic atmosphere.

When you don’t plan your trips and vacations with reservations, you often find yourself with no place to stay, or a place that isn’t what you have in mind. By planning ahead and booking your space with a resort, you’ll be guaranteed a room in a clean, comfortable and safe location. This allows you to enjoy the trip doing the things you want to do and make memories that last forever.

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Common use

The main component of Viagra is Sildenafil Citrate.
Sildenafil Citrate affects the response to sexual stimulation. It acts by enhancing smooth muscle relaxation using nitric oxide, a chemical that is normally released in response to sexual stimulation. This smooth muscle relaxation allows increased blood flow into certain areas of the penis, which leads to an erection.
Sildenafil Citrate is applied for the treatment of erectile dysfunction (impotence) in men and pulmonary arterial hypertension.
Sildenafil Citrate may also be used for other purposes not listed above.

Dosage and direction

Usually the recommended dose is 50 mg. It is taken approximately 0,5-1 hour before sexual activity. Do not take Viagra more then once a day.
A high fat meal may delay the time of the effect of this drug.
Try not to eat grapefruit or drink grapefruit juice while you are being treated with Sildenafil Citrate .

Precautions

Before you start taking Sildenafil Citrate. tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
Aged people may be more sensitive to the side effects of the drug.

Viagra is contraindicated in patients who take another medicine to treat impotence or using a nitrate drug for chest pain or heart problems.
This medicine should not be taken by women and children as well as in patients with a known hypersensitivity to any component of the tablet.

Possible side effect

The most common side effects are headache, flushing, heartburn, stomach upset, nasal stuffiness, lightheadedness, dizziness or diarrhea.
A serious allergic reaction to this drug is very rare, but seek immediate medical help if it occurs.
Many people who use this medicine do not have serious side effects.
In case you notice any side effects not listed above, contact your doctor or pharmacist.

Drug interaction

This drug should not be used with nitrates and recreational drugs called “poppers” containing amyl or butyl nitrite; alpha-blocker medications; other medications for impotence; high blood pressure medicines, etc.
Consult your doctor or pharmacist for more details.

Missed dose

Viagra is used as needed, so you are unlikely to be on a dosing schedule.

Overdose

If you think you have used too much of this medicine seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Storage

Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store the drugs in the bathroom. Keep all drugs away from reach of children and pets.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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